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in the survival of cancer patients. Therefore, we aimed to determine the association between obesity and the PFS of surgically treated breast cancer patients.
Recently, obesity has been studied as a result of its effects on the incidence of breast cancer, as well as its association with the tumor characteristics. High body fat mass has been reported to decrease the response to systemic therapies by reducing the distribution and accumulation of various drugs in tumor tissues \[[@CR17], [@CR22]\]. In the body, excess body fat and visceral adipose tissue are known to affect the production of adipokines including leptin, resistin and tumor necrosis factor-α (TNF-α) \[[@CR23]\]. In addition, high body fat mass decreases the activity of human adipose tissue and the synthesis of glucocorticoid and sex steroid hormones \[[@CR24]\]. Furthermore, obese patients are likely to have a higher ratio of estrogen to androgen and lower ratio of estrogen to cortisol than their non-obese counterparts, thus increasing the risk of breast cancer \[[@CR25]\]. It has been reported that obesity is associated with a relatively poor prognosis of cancer patients \[[@CR26]\]. Although the relationship between obesity and cancer prognosis has been studied for many years, the results are still controversial \[[@CR27]\].
In this study, we analyzed the effect of obesity on the survival of breast cancer patients who received surgical treatment. When analyzing breast cancer patients treated with surgery alone, we found that obesity is significantly associated with higher PFS rates in breast cancer patients. Our result is similar to previous study \[[@CR28]\]. The result of this study suggests that the prognosis of breast cancer patients with high BMI and normal WC may be better than those with normal BMI and high WC. Therefore, patients with increased WC who have a high risk of breast cancer can be effectively diagnosed through patient history and physical examination. These patients should be informed of the increased prognosis of the cancer and that they should maintain a healthy life style for a better prognosis. They can also receive early detection, and receive personalized chemotherapy and hormone therapy that will increase the patient’s survival
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